冯明昊

Feng Minghao

绿色化学与工程研究院

研究员、助理教授

个人简介

冯明昊,研究员,准聘助理教授,课题组组长。2012年本科毕业于华东师范大学化学系,后直博进入华东师范大学化学与分子工程学院姜雪峰教授课题组。2017取得博士学位后,先后在法国原子能研究所(CEA)碳同位素标记实验室和奥地利维也纳大学世界知名有机化学家Nuno Maulide课题组从事博士后研究工作,期间获得欧盟玛丽居里Eurotalent基金和奥地利Lise Meitner基金。20232月,冯明昊博士回到法国原子能研究所任研究员,主持开展氮同位素标记相关研究。于20241月回国加入南京大学化学与化工学院,在苏州校区绿色化学与工程研究院开展独立工作。冯明昊博士研究方向为同位素药物标记和精细化学品合成,目前已发表了20余篇学术论文及专利,其中第一作者论文12篇,包括Chem1篇),J. Am. Chem. Soc.2篇),Angew. Chem. Int. Ed.4篇),Org. Lett.Chem. Comm.Synthesis5篇。

课题组招收硕士和博士研究生,同时拟招聘博士后1—2人、科研助理及联合培养学生若干人,欢迎具有化学、材料或物理专业背景的有志青年加入!有志加入请联系minghao.feng@nju.edu.cn.

代表性论文:

1. Feng, M.; Norlöff, N.; Guichard, B.; Kealey, S.; Thuéry, P.; Gee, A.; Feuillastre, S.; Audisio, D. “Pyridine-based Strategy towards Nitrogen Isotope Exchange.” Submitted. For preprint version, please see: 10.26434/chemrxiv-2023-r0xn7.

2. Feng, M.; Fernandes-Goodall, A.; Meyrelles, R. Maulide, N. “Direct Enantioselective a-Amination of Amides Guided by DFT Prediction of E/Z Selectivity in a Sulfonium Intermediate.” Chem, 2023, 9, 1538.

3. Feng, M.; Fernandes-Goodall, A.; Spinozzi, Eleonora; Shaaban, S.; Maulid, N. “a-Amination of Carbonyls through Electrophilic Activation with Sulfinamides.” Angew. Chem. Int. Ed.2023, 62, e202304990.

4. Feng, M.;Tinelli, R.; Meyrelles, R.; González, L.; Maryasin, B.; Maulide, N. “Direct Synthesis of α-Amino Acid Derivatives by Hydrative Amination of Alkynes.”Angew. Chem. Int. Ed.2023, 62, e202212399.

5. Feng, M.; Mosiagin, I.; Kaiser, D.; Maryasin, B.; Maulide, N. “Deployment of Sulfinimines in Charge-Accelerated Sulfonium Rearrangement Enables a Surrogate Asymmetric Mannich Reaction.” J. Am. Chem. Soc.2022144‚ 13044.

6. Feng, M.; Zhang, H.; Maulide, N. “Challenges and Breakthroughs in Selective Amide Activation.” Angew. Chem. Int. Ed. 2022, 61, e202212213.

7. Feng, M.; De Oliveira, J.; Sallustrau, A.; Destro, G.; Thuéry, P.; Roy, S.; Cantat, T.; Elmore, C. S.; Blankenstein, J.; Taran, F.; Audisio, D. “Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation.” J. Am. Chem. Soc., 2021143‚ 5659.

8. Feng, M.; Tang, B.; Wang, N.; Xu, H.; Jiang, X. “Ligand Controlled Regiodivergent C-1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids.” Angew. Chem. Int. Ed., 201554‚ 14960.

9. Feng, M.;Madegard, L.; Riomet, M.; Louis, M.; Champagne, P. A.; Pieters, G.; Audisio, D.; Taran, F. “Selective Chlorination of Iminosydnones for Fast Release of Amide, Sulfonamide and Urea-Containing Drugs.” Chem. Commun. 2022, 58, 8500.

10. Feng, M.; Tang, B.; Xu, H.; Jiang, X. “Collective Synthesis of Phenanthridinone through C-H Activation Involving Pd-Catalyzed Aryne Multicomponent Reaction” Org. Lett., 201618‚ 4352.


英文简介

Feng Minghao, principal investigator, tenure-track assistant professor. Minghao graduated from the Department of Chemistry of East China Normal University (ECNU) with a bachelor’s degree in 2012. Then he joined Professor Jiang Xuefeng’s research group at ECNU as a PhD candidate. After obtaining his PhD in 2017, he engaged in postdoctoral research in the Carbon Isotope Labeling Laboratory of the French Institute of Atomic Energy (CEA) and the research group of Nuno Maulide, at the University of Vienna in Austria. During this period, he received the Marie Curie Eurotalent Fellowship and the Lise Meitner fellowship. In February 2023, Minghao returned to the French Institute of Atomic Energy as a CDD researcher and led research related to nitrogen isotope labeling. Minghao to join The Institute of Green Chemistry and Engineering, School of Chemistry and Chemical Engineering, Nanjing University and started his independent research at Suzhou campus. Dr. Feng Minghao’s research interests include drug isotopic labeling and fine chemical synthesis. He has published more than 20 papers and 12 papers are published as the first author, including Chem (1), J. Am. Chem. Soc. (2), Angew. Chem. Int. Ed. (4), etc.

Representative Papers:

1. Feng, M.; Norlöff, N.; Guichard, B.; Kealey, S.; Thuéry, P.; Gee, A.; Feuillastre, S.; Audisio, D. “Pyridine-based Strategy towards Nitrogen Isotope Exchange.” Submitted. For preprint version, please see: 10.26434/chemrxiv-2023-r0xn7.

2. Feng, M.; Fernandes-Goodall, A.; Meyrelles, R. Maulide, N. “Direct Enantioselective a-Amination of Amides Guided by DFT Prediction of E/Z Selectivity in a Sulfonium Intermediate.” Chem, 2023, 9, 1538.

3. Feng, M.; Fernandes-Goodall, A.; Spinozzi, Eleonora; Shaaban, S.; Maulid, N. “a-Amination of Carbonyls through Electrophilic Activation with Sulfinamides.” Angew. Chem. Int. Ed.2023, 62, e202304990.

4. Feng, M.;Tinelli, R.; Meyrelles, R.; González, L.; Maryasin, B.; Maulide, N. “Direct Synthesis of α-Amino Acid Derivatives by Hydrative Amination of Alkynes.”Angew. Chem. Int. Ed.2023, 62, e202212399.

5. Feng, M.; Mosiagin, I.; Kaiser, D.; Maryasin, B.; Maulide, N. “Deployment of Sulfinimines in Charge-Accelerated Sulfonium Rearrangement Enables a Surrogate Asymmetric Mannich Reaction.” J. Am. Chem. Soc.2022144‚ 13044.

6. Feng, M.; Zhang, H.; Maulide, N. “Challenges and Breakthroughs in Selective Amide Activation.” Angew. Chem. Int. Ed. 2022, 61, e202212213.

7. Feng, M.; De Oliveira, J.; Sallustrau, A.; Destro, G.; Thuéry, P.; Roy, S.; Cantat, T.; Elmore, C. S.; Blankenstein, J.; Taran, F.; Audisio, D. “Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation.” J. Am. Chem. Soc., 2021143‚ 5659.

8. Feng, M.; Tang, B.; Wang, N.; Xu, H.; Jiang, X. “Ligand Controlled Regiodivergent C-1 Insertion on Arynes for Construction of Phenanthridinone and Acridone Alkaloids.” Angew. Chem. Int. Ed., 201554‚ 14960.

9. Feng, M.;Madegard, L.; Riomet, M.; Louis, M.; Champagne, P. A.; Pieters, G.; Audisio, D.; Taran, F. “Selective Chlorination of Iminosydnones for Fast Release of Amide, Sulfonamide and Urea-Containing Drugs.” Chem. Commun. 2022, 58, 8500.

10. Feng, M.; Tang, B.; Xu, H.; Jiang, X. “Collective Synthesis of Phenanthridinone through C-H Activation Involving Pd-Catalyzed Aryne Multicomponent Reaction” Org. Lett., 201618‚ 4352.